製品: DLG3 Antibody
カタログ: DF9443
タンパク質の説明: Rabbit polyclonal antibody to DLG3
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Sheep, Rabbit, Dog, Chicken
分子量: 90 kDa; 90kD(Calculated).
ユニプロット: Q92796
RRID: AB_2842639

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Zebrafish(82%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
クローナリティ:
Polyclonal
特異性:
DLG3 Antibody detects endogenous levels of total DLG3.
RRID:
AB_2842639
引用形式: Affinity Biosciences Cat# DF9443, RRID:AB_2842639.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

bA291O7.3; bA291O7.3 discs large Drosophila homolog 3 neuroendocrine dlg; Discs large Drosophila homolog 3; Discs large homolog 3 neuroendocrine dlg Drosophila; Discs large homolog 3; Discs large homolog 3 Drosophila; Discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG 3; Dlg3; DLG3_HUMAN; KIAA1232; mKIAA1232; MRX 90; MRX; MRX90; NE Dlg; NEDLG; Neuroendocrine dlg; Neuroendocrine-DLG; OTTHUMP00000023475; OTTHUMP00000023476; OTTHUMP00000023477; SAP 102; SAP-102; SAP102; Synapse associated protein 102; Synapse-associated protein 102; XLMR;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASAGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Zebrafish
82
Horse
0
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q92796 基板として

Site PTM Type Enzyme
T78 Phosphorylation
T112 Phosphorylation
Y117 Phosphorylation
S123 Phosphorylation
T163 Phosphorylation
K268 Ubiquitination
Y306 Phosphorylation
S458 Phosphorylation
S487 Phosphorylation
S488 Phosphorylation
S490 Phosphorylation
S491 Phosphorylation
S495 Phosphorylation
S503 Phosphorylation
Y505 Phosphorylation
T515 Phosphorylation
T550 Phosphorylation
S589 Phosphorylation
Y626 Phosphorylation
K637 Ubiquitination
T660 Phosphorylation
Y673 Phosphorylation
S678 Phosphorylation
T759 Phosphorylation
Y760 Phosphorylation
K765 Acetylation
Y808 Phosphorylation
S813 Phosphorylation

研究背景

機能:

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

サブユニット構造:

Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts with FLTP/C1orf192 (By similarity). Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4.

タンパク質ファミリー:

Belongs to the MAGUK family.

研究領域

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

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