POLE2 Antibody - #DF9446
| 製品: | POLE2 Antibody |
| カタログ: | DF9446 |
| タンパク質の説明: | Rabbit polyclonal antibody to POLE2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| 分子量: | 60 kDa; 60kD(Calculated). |
| ユニプロット: | P56282 |
| RRID: | AB_2842642 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9446, RRID:AB_2842642.
折りたたみ／展開
DNA polymerase epsilon subunit 2; DNA polymerase epsilon subunit B; DNA polymerase II subunit 2; DPE 2; DPE2; DPOE2_HUMAN; POLE 2; POLE2; Polymerase (DNA directed) epsilon 2 (p59 subunit); Polymerase (DNA directed) epsilon 2; polymerase (DNA directed), epsilon 2, accessory subunit; Polymerase, DNA, epsilon-2;
免疫原
- P56282 DPOE2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSNMIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGDAIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEVLEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSRFVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLVNKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P56282 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K15 | Ubiquitination | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| T112 | Phosphorylation | Uniprot | |
| T122 | Phosphorylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| K191 | Acetylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| K276 | Ubiquitination | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| Y465 | Phosphorylation | Uniprot | |
| Y467 | Phosphorylation | Uniprot | |
| K517 | Ubiquitination | Uniprot | |
| K523 | Ubiquitination | Uniprot |
研究背景
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity).
Nucleus.
Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4.
Belongs to the DNA polymerase epsilon subunit B family.
研究領域
· Genetic Information Processing > Replication and repair > DNA replication.
· Genetic Information Processing > Replication and repair > Base excision repair.
· Genetic Information Processing > Replication and repair > Nucleotide excision repair.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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