MARCH6 Antibody - #DF9482
| 製品: | MARCH6 Antibody |
| カタログ: | DF9482 |
| タンパク質の説明: | Rabbit polyclonal antibody to MARCH6 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Zebrafish, Rabbit, Chicken, Xenopus |
| 分子量: | 103 kDa; 103kD(Calculated). |
| ユニプロット: | O60337 |
| RRID: | AB_2842678 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9482, RRID:AB_2842678.
折りたたみ／展開
DOA10; Doa10 homolog; E3 ubiquitin protein ligase MARCH6; KIAA0597; MARCH 6; MARCH VI; MARCHVI; Membrane associated RING CH protein VI; Membrane associated ring finger (C3HC4) 6; Membrane associated RING finger protein 6; Protein TEB 4; Protein TEB4; RING finger protein 176; RNF 176; RNF176; TEB 4; TEB4;
免疫原
- O60337 MARH6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60337 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| T17 | Phosphorylation | Uniprot | |
| K20 | Ubiquitination | Uniprot | |
| T29 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| Y474 | Phosphorylation | Uniprot | |
| K550 | Ubiquitination | Uniprot | |
| Y850 | Phosphorylation | Uniprot | |
| Y874 | Phosphorylation | Uniprot | |
| K878 | Ubiquitination | Uniprot | |
| K881 | Ubiquitination | Uniprot | |
| Y882 | Phosphorylation | Uniprot | |
| K897 | Ubiquitination | Uniprot |
研究背景
E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
Auto-ubiquitinated, which results in proteasomal degradation.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Present in brain (at protein level).
Interacts with DIO2. Interacts with SQLE.
The RING-CH-type zinc finger domain is required for E3 ligase activity.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.