NTHL1 Antibody - #DF9498
| 製品: | NTHL1 Antibody |
| カタログ: | DF9498 |
| タンパク質の説明: | Rabbit polyclonal antibody to NTHL1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Monkey |
| 予測: | Pig, Zebrafish, Bovine, Horse, Chicken, Xenopus |
| 分子量: | 34 kDa; 34kD(Calculated). |
| ユニプロット: | P78549 |
| RRID: | AB_2842694 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9498, RRID:AB_2842694.
折りたたみ／展開
Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; Endonuclease III like protein 1; Endonuclease III-like protein 1; hNTH1; NTH 1; nth endonuclease III like 1 (E. coli); NTH endonuclease III Like 1; NTH1; NTHL 1; Nthl1; NTHL1_HUMAN; OCTS 3; OCTS3;
免疫原
- P78549 NTH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCSPQESGMTALSARMLTRSRSLGPGAGPRGCREEPGPLRRREAAAEARKSHSPVKRPRKAQRLRVAYEGSDSEKGEGAEPLKVPVWEPQDWQQQLVNIRAMRNKKDAPVDHLGTEHCYDSSAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANRLRWTKKATKSPEETRAALEEWLPRELWHEINGLLVGFGQQTCLPVHPRCHACLNQALCPAAQGL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P78549 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| R21 | Methylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| Y68 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| T160 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| T171 | Phosphorylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| Y177 | Phosphorylation | Uniprot |
研究背景
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Nucleus. Mitochondrion.
Widely expressed with highest levels in heart and lowest levels in lung and liver.
Interacts with YBX1.
Belongs to the Nth/MutY family.
研究領域
· Genetic Information Processing > Replication and repair > Base excision repair.
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