GCFC1 Antibody - #DF9529
| 製品: | GCFC1 Antibody |
| カタログ: | DF9529 |
| タンパク質の説明: | Rabbit polyclonal antibody to GCFC1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 105 kDa; 105kD(Calculated). |
| ユニプロット: | Q9Y5B6 |
| RRID: | AB_2842725 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9529, RRID:AB_2842725.
折りたたみ／展開
BM 020; BM020; Chromosome 21 open reading frame 66; FSAP105; Functional spliceosome-associated protein 105; GC rich sequence DNA binding factor candidate; GC-rich sequence DNA-binding factor 1; GCFC; GCFC1; GCFC1_HUMAN; PAX3 and PAX7 binding protein 1; PAXBP1;
免疫原
- Q9Y5B6 PAXB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHNVKEFKSLIEGK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y5B6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K121 | Methylation | Uniprot | |
| K123 | Methylation | Uniprot | |
| K149 | Sumoylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| K164 | Acetylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| K193 | Acetylation | Uniprot | |
| K197 | Sumoylation | Uniprot | |
| T242 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K278 | Acetylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| Y476 | Phosphorylation | Uniprot | |
| K492 | Sumoylation | Uniprot | |
| Y521 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| T563 | Phosphorylation | Uniprot | |
| K624 | Ubiquitination | Uniprot | |
| K682 | Ubiquitination | Uniprot | |
| Y718 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| T729 | Phosphorylation | Uniprot | |
| Y855 | Phosphorylation | Uniprot |
研究背景
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).
Nucleus.
Ubiquitous.
Interacts with PAX3 and PAX7. Interacts with WDR5; associates with a histone methyltransferase (HMT) complex composed at least of RBBP5, ASH2L, SET1, SET2 and KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4 through direct interaction with WDR5 (By similarity).
Belongs to the GCF family.
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