GNG12 Antibody - #DF9556

(1)  
製品: GNG12 Antibody
カタログ: DF9556
タンパク質の説明: Rabbit polyclonal antibody to GNG12
アプリケーション: WB IHC
反応性: Human, Mouse, Monkey
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 8 kDa; 8kD(Calculated).
ユニプロット: Q9UBI6
RRID: AB_2842752

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関連ダウンロード
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Monkey
予測:
Pig(88%), Bovine(88%), Horse(100%), Sheep(88%), Rabbit(100%), Dog(100%), Chicken(86%)
クローナリティ:
Polyclonal
特異性:
GNG12 Antibody detects endogenous levels of total GNG12.
RRID:
AB_2842752
引用形式: Affinity Biosciences Cat# DF9556, RRID:AB_2842752.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

G-protein gamma-12 subunit; GNG12; Guanine nucleotide binding protein (G protein) gamma 12; guanine nucleotide-binding protein G(I)/G(S)/G(O); Hypothetical protein DKFZp762E193;

免疫原

免疫原:
Uniprot:

Q9UBI6(GBG12_HUMAN) >>Visit HPA database.

遺伝子(ID):
GNG12(55970)
タンパク質配列:
MSSKTASTNNIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLIGIPTSENPFKDKKTCIIL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Dog
100
Rabbit
100
Pig
88
Bovine
88
Sheep
88
Chicken
86
Xenopus
63
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9UBI6 基板として

Site PTM Type Enzyme
S2 Acetylation
S2 Phosphorylation
K4 Ubiquitination
T5 Phosphorylation
S7 Phosphorylation
T8 Phosphorylation
S26 Phosphorylation
K34 Ubiquitination
S41 Phosphorylation
Y42 Phosphorylation
C43 S-Nitrosylation
S49 Phosphorylation
K64 Ubiquitination

研究背景

機能:

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

細胞の位置付け:

Cell membrane>Lipid-anchor>Cytoplasmic side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

G proteins are composed of 3 units, alpha, beta and gamma.

タンパク質ファミリー:

Belongs to the G protein gamma family.

研究領域

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Apelin signaling pathway.   (View pathway)

· Human Diseases > Substance dependence > Morphine addiction.

· Human Diseases > Substance dependence > Alcoholism.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

· Organismal Systems > Environmental adaptation > Circadian entrainment.

· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling.   (View pathway)

· Organismal Systems > Nervous system > Glutamatergic synapse.

· Organismal Systems > Nervous system > Cholinergic synapse.

· Organismal Systems > Nervous system > Serotonergic synapse.

· Organismal Systems > Nervous system > GABAergic synapse.

· Organismal Systems > Nervous system > Dopaminergic synapse.

· Organismal Systems > Endocrine system > Relaxin signaling pathway.

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