KIR2DS5 Antibody - #DF9601
| 製品: | KIR2DS5 Antibody |
| カタログ: | DF9601 |
| タンパク質の説明: | Rabbit polyclonal antibody to KIR2DS5 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 分子量: | 34 kDa; 34kD(Calculated). |
| ユニプロット: | Q14953 |
| RRID: | AB_2842797 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9601, RRID:AB_2842797.
折りたたみ／展開
CD158 antigen like family member G; CD158g; Flags: Precursor; Killer cell immunoglobulin like receptor 2DS5; Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 5; KIR2DS5; MHC class I NK cell receptor; Natural killer associated transcript 9; Natural killer cell inhibitory receptor; NKAT 9; NKAT9;
免疫原
- Q14953 KI2S5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLMVISMACVAFFLLQGAWPHEGFRRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGTFNHTLRLIGEHIDGVSKGNFSIGRMTQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNRTFQADFPLDPATHGGTYRCFGSFRDSPYEWSKSSDPLLVSVTGNSSNSWPSPTEPSSETGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSNKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA
PTMs - Q14953 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N178 | N-Glycosylation | Uniprot |
研究背景
Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity. Able to activate NK cells citotoxicity and cytokine production such as IFNG. Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry.
N-glycosylated, glycosylation varies depending on the allele which alters cell surface expression levels.
Cell membrane>Single-pass type I membrane protein>Extracellular side.
Expressed on a discrete subset of peripheral blood NK cells.
Interacts with TYROBP.
Belongs to the immunoglobulin superfamily.
研究領域
· Organismal Systems > Immune system > Antigen processing and presentation. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
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