LRP12 Antibody - #DF9608
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9608, RRID:AB_2842804.
折りたたみ／展開
AI848829; FLJ12929; Low density lipoprotein receptor related protein 12; Low-density lipoprotein receptor-related protein 12; LRP 12; LRP-12; LRP12; LRP12_HUMAN; ST7; Suppressor of tumorigenicity 7 protein;
免疫原
Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
- Q9Y561 LRP12_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y561 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T7 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| R432 | Methylation | Uniprot | |
| Y435 | Phosphorylation | Uniprot | |
| T495 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| T515 | Phosphorylation | Uniprot | |
| S584 | Phosphorylation | Uniprot | |
| T589 | Phosphorylation | Uniprot | |
| S617 | Phosphorylation | Uniprot | |
| S631 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| T655 | Phosphorylation | Uniprot | |
| T657 | Phosphorylation | Uniprot | |
| K678 | Ubiquitination | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S749 | Phosphorylation | Uniprot | |
| S755 | Phosphorylation | Uniprot | |
| S851 | Phosphorylation | Uniprot |
研究背景
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Membrane>Single-pass type I membrane protein. Membrane>Coated pit.
Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
May interact with RACK1, ZFYVE9 and NMRK2.
Belongs to the LDLR family.
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