MARVELD2 Antibody - #DF9611
| 製品: | MARVELD2 Antibody |
| カタログ: | DF9611 |
| タンパク質の説明: | Rabbit polyclonal antibody to MARVELD2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 64 kDa; 64kD(Calculated). |
| ユニプロット: | Q8N4S9 |
| RRID: | AB_2842807 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9611, RRID:AB_2842807.
折りたたみ／展開
DFNB49; FLJ30532; MARVD2; MARVEL (membrane associating) domain containing 2; MARVEL domain containing 2; MARVEL domain containing protein 2; MARVELD 2; MARVELD2; MRVLDC2; Tric; Tricellulin;
免疫原
- Q8N4S9 MALD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNDGRSRNRDRRYDEVPSDLPYQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFFRGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPYGSLDRHTQTVRTYSEKVEEYNLRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGYSQPYGMGGVGGLGSMYGGYYYTGPKTPFVLVVAGLAWITTIIILVLGMSMYYRTILLDSNWWPLTEFGINVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPVNAVFCRVEGGQIAAMIFLFVTMIVYLISALVCLKLWRHEAARRHREYMEQQEINEPSLSSKRKMCEMATSGDRQRDSEVNFKELRTAKMKPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDDERERYKAVFQDQFSEYKELSAEVQAVLRKFDELDAVMSRLPHHSESRQEHERISRIHEEFKKKKNDPTFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDVQGYS
PTMs - Q8N4S9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y14 | Phosphorylation | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| T27 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| Y159 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| T166 | Phosphorylation | Uniprot | |
| T168 | Phosphorylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| Y377 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| Y442 | Phosphorylation | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| Y469 | Phosphorylation | Uniprot | |
| K548 | Ubiquitination | Uniprot | |
| Y557 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot |
研究背景
Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.
Ubiquitinated by ITCH; but this ubiquitination does not lead to proteasomal degradation.
Phosphorylated.
Cell membrane>Multi-pass membrane protein. Cell junction>Tight junction.
Note: Found at tricellular contacts.
Interacts with TJP1. Interacts with the ubiquitin ligase ITCH.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
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