MAP1A Antibody - #DF9623

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製品: MAP1A Antibody
カタログ: DF9623
タンパク質の説明: Rabbit polyclonal antibody to MAP1A
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Horse, Sheep, Dog
分子量: 305kDa; 305kD(Calculated).
ユニプロット: P78559
RRID: AB_2842819

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IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Horse(100%), Sheep(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
MAP1A Antibody detects endogenous levels of total MAP1A.
RRID:
AB_2842819
引用形式: Affinity Biosciences Cat# DF9623, RRID:AB_2842819.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

MAP 1A; MAP 1L; MAP-1A; MAP1 light chain LC2; Map1a; MAP1A_HUMAN; MAP1L; Microtubule associated protein 1 like; Microtubule associated protein 1A; MTAP 1A; MTAP1A; Proliferation related protein p80; Proliferation-related protein p80;

免疫原

免疫原:
Uniprot:

P78559(MAP1A_HUMAN) >>Visit HPA database.

遺伝子(ID):
MAP1A(4130)
発現特異性:
P78559 MAP1A_HUMAN:

Brain.

タンパク質配列:
MDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPEKLRLPDASRKAKRSIEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEMQFLMQKWAGNSKAKTGIVLPNGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNKILEGLEKLRHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKKDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKISKPDLKPFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPTISGHRELVLSSPEDLTQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGLGQEEHVMKEKELVPEVPEEQGSKDRGLDSGAETEEEKDTWEEKKQREAERLPDRTEAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEDATKAEGFYQKHMQEPLKVTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGATEHVSYIQDETIPGYSETEQTISDEEIHDEPEERPAPPRFHTSTYDLPGPEGAGPFEASQPADSAVPATSGKVYGTPETELTYPTNIVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPCEDFSVTGESEKRGEIIGKGLSGERAVEEEEEETANVEMSEKLCSQYGTPVFSAPGHALHPGEPALGEAEERCLSPDDSTVKMASPPPSGPPSATHTPFHQSPVEEKSEPQDFQEADSWGDTKRTPGVGKEDAAEETVKPGPEEGTLEKEEKVPPPRSPQAQEAPVNIDEGLTGCTIQLLPAQDKAIVFEIMEAGEPTGPILGAEALPGGLRTLPQEPGKPQKDEVLRYPDRSLSPEDAESLSVLSVPSPDTANQEPTPKSPCGLTEQYLHKDRWPEVSPEDTQSLSLSEESPSKETSLDVSSKQLSPESLGTLQFGELNLGKEEMGHLMQAEDTSHHTAPMSVPEPHAATASPPTDGTTRYSAQTDITDDSLDRKSPASSFSHSTPSGNGKYLPGAITSPDEHILTPDSSFSKSPESLPGPALEDIAIKWEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQKDTALEQKDKALEPKDKDLEEKDKALEQKDKIPEEKDKALEQKDTALEQKDKALEPKDKDLEQKDRVLEQKEKIPEEKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKDEALEQNIQALEENHQTQEQESLVQEDKTRKPKMLEEKSPEKVKAMEEKLEALLEKTKALGLEESLVQEGRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQKELAPAWEDTSPEQDNRYWRGREDVALEQDTYWRELSCERKVWFPHELDGQGARPHYTEERESTFLDEGPDDEQEVPLREHATRSPWASDFKDFQESSPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMVGQRVPSAPGQESPIPDPKLMPHMKNEPTTPSWLADIPPWVPKDRPLPPAPLSPAPGPPTPAPESHTPAPFSWGTAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREEEGRAEAPDKSSHSSKVPEASKSHATTEPEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGAAGDWPPCLSTKEAAAGRNTSAEKELSSPISPKSLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKEAQSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPSLDFPASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLALAPAPSLPGDMGDGILPCHLECSEAATEKPSPFQVPSEDCAANGPTETSPNPPGPAPAKAENEEAAACPAWERGAWPEGAERSSRPDTLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEPRPHRGELSPSFLNPPLPPSIDDRDLSTEEVRLVGRGGRRRVGGPGTTGGPCPVTDETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPLPQPDPRPSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGRRAPGKAKPASPARRLDLRGKRSPTPGKGPADRASRAPPRPRSTTSQVTPAEEKDGHSPMSKGLVNGLKAGPMALSSKGSSGAPVYVDLAYIPNHCSGKTADLDFFRRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFPACKIEF

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Sheep
100
Dog
100
Bovine
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P78559 基板として

Site PTM Type Enzyme
K37 Ubiquitination
K105 Ubiquitination
S114 Phosphorylation
S117 Phosphorylation
S118 Phosphorylation
S119 Phosphorylation
Y120 Phosphorylation
S121 Phosphorylation
S129 Phosphorylation
K142 Ubiquitination
S155 Phosphorylation
Y177 Phosphorylation
K192 Ubiquitination
K207 Ubiquitination
S209 Phosphorylation
K218 Ubiquitination
S223 Phosphorylation
K226 Ubiquitination
T227 Phosphorylation
T259 Phosphorylation
K275 Ubiquitination
K282 Ubiquitination
K297 Ubiquitination
S319 Phosphorylation
S322 Phosphorylation
T382 Phosphorylation
S384 Phosphorylation
K394 Acetylation
K397 Acetylation
K403 Acetylation
K431 Acetylation
K448 Acetylation
K453 Acetylation
S460 Phosphorylation
T468 Phosphorylation
S500 Phosphorylation
T504 Phosphorylation
S518 Phosphorylation
S526 Phosphorylation
S527 Phosphorylation
T532 Phosphorylation
K539 Acetylation
T576 Phosphorylation
S605 Phosphorylation
S612 Phosphorylation
T616 Phosphorylation
T622 Phosphorylation
S644 Phosphorylation
S667 Phosphorylation
T675 Phosphorylation
Y681 Phosphorylation
T692 Phosphorylation
S771 Phosphorylation
T772 Phosphorylation
Y773 Phosphorylation
S787 Phosphorylation
T804 Phosphorylation
S874 Phosphorylation
S891 Phosphorylation
T894 Phosphorylation
S896 Phosphorylation
T898 Phosphorylation
S899 Phosphorylation
S900 Phosphorylation
S909 Phosphorylation
S916 Phosphorylation
T918 Phosphorylation
S956 Phosphorylation
Y958 Phosphorylation
T960 Phosphorylation
S964 Phosphorylation
S986 Phosphorylation
S996 Phosphorylation
S1000 Phosphorylation
S1004 Phosphorylation
T1006 Phosphorylation
T1008 Phosphorylation
S1013 Phosphorylation
S1029 Phosphorylation
T1036 Phosphorylation
T1057 Phosphorylation
S1069 Phosphorylation
S1144 Phosphorylation
S1146 Phosphorylation
S1152 Phosphorylation
S1160 Phosphorylation
T1163 Phosphorylation
T1169 Phosphorylation
S1172 Phosphorylation
T1177 Phosphorylation
S1190 Phosphorylation
S1196 Phosphorylation
S1198 Phosphorylation
S1200 Phosphorylation
S1203 Phosphorylation
S1209 Phosphorylation
S1213 Phosphorylation
S1218 Phosphorylation
S1221 Phosphorylation
T1224 Phosphorylation
S1264 Phosphorylation
S1274 Phosphorylation
S1283 Phosphorylation
S1288 Phosphorylation
S1291 Phosphorylation
S1292 Phosphorylation
S1299 Phosphorylation
S1311 Phosphorylation
T1318 Phosphorylation
S1321 Phosphorylation
S1322 Phosphorylation
S1326 Phosphorylation
S1329 Phosphorylation
Y1388 Phosphorylation
K1406 Acetylation
K1411 Acetylation
Y1555 Phosphorylation
S1600 Phosphorylation
S1626 Phosphorylation
Y1640 Phosphorylation
T1653 Phosphorylation
S1654 Phosphorylation
T1674 Phosphorylation
S1675 Phosphorylation
Y1682 Phosphorylation
T1695 Phosphorylation
Y1696 Phosphorylation
S1701 Phosphorylation
Y1721 Phosphorylation
S1727 Phosphorylation
T1728 Phosphorylation
T1747 Phosphorylation
S1749 Phosphorylation
S1761 Phosphorylation
S1762 Phosphorylation
S1776 Phosphorylation
S1791 Phosphorylation
S1797 Phosphorylation
S1801 Phosphorylation
S1812 Phosphorylation
S1818 Phosphorylation
T1834 Phosphorylation
T1835 Phosphorylation
S1837 Phosphorylation
S1858 Phosphorylation
T1865 Phosphorylation
Y1883 Phosphorylation
Y1902 Phosphorylation
S1903 Phosphorylation
Y1909 Phosphorylation
T1957 Phosphorylation
Y1959 Phosphorylation
S1964 Phosphorylation
Y1971 Phosphorylation
S2012 Phosphorylation
S2018 Phosphorylation
S2019 Phosphorylation
S2022 Phosphorylation
T2042 Phosphorylation P28482 (MAPK1)
S2052 Phosphorylation
S2056 Phosphorylation
T2058 Phosphorylation
S2074 Phosphorylation
S2085 Phosphorylation
S2090 Phosphorylation
S2092 Phosphorylation
S2104 Phosphorylation
T2105 Phosphorylation
S2106 Phosphorylation
S2108 Phosphorylation
S2182 Phosphorylation
S2188 Phosphorylation
S2193 Phosphorylation
S2197 Phosphorylation
T2210 Phosphorylation
Y2217 Phosphorylation
S2235 Phosphorylation
S2238 Phosphorylation
S2252 Phosphorylation
S2256 Phosphorylation
S2259 Phosphorylation
S2366 Phosphorylation
S2408 Phosphorylation
S2419 Phosphorylation P28482 (MAPK1)
S2425 Phosphorylation
S2427 Phosphorylation
S2449 Phosphorylation
S2451 Phosphorylation
S2467 Phosphorylation
S2533 Phosphorylation
S2571 Phosphorylation
K2612 Acetylation
K2614 Acetylation
S2617 Phosphorylation
R2628 Methylation
S2629 Phosphorylation
T2631 Phosphorylation
S2649 Phosphorylation
T2655 Phosphorylation
S2664 Phosphorylation
S2667 Phosphorylation
S2682 Phosphorylation
S2683 Phosphorylation
K2684 Ubiquitination
K2705 Ubiquitination
T2706 Phosphorylation

研究背景

機能:

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

PTMs:

Phosphorylated by CSNK1D.

LC2 is generated from MAP1A by proteolytic processing.

細胞の位置付け:

Cytoplasm>Cytoskeleton.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Brain.

サブユニット構造:

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity). MAP1 light chain LC2: Interacts with ELAVL4 (By similarity).

タンパク質ファミリー:

The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.

Belongs to the MAP1 family.

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