NNT Antibody - #DF9658
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9658, RRID:AB_2842854.
折りたたみ／展開
GCCD4; mitochondrial; NAD(P) transhydrogenase; NAD(P) transhydrogenase mitochondrial; Nicotinamide nucleotide transhydrogenase; NNT; NNTM; NNTM_HUMAN; Pyridine nucleotide transhydrogenase;
免疫原
Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.
- Q13423 NNTM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVLASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQVPRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMGHVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYTAGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLLNAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13423 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K49 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K63 | Acetylation | Uniprot | |
| K70 | Acetylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K117 | Acetylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| K202 | Acetylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K323 | Acetylation | Uniprot | |
| K331 | Acetylation | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| Y373 | Phosphorylation | Uniprot | |
| T374 | Phosphorylation | Uniprot | |
| T382 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| K394 | Acetylation | Uniprot | |
| K397 | Acetylation | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| Y407 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| K451 | Ubiquitination | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| S677 | Phosphorylation | Uniprot | |
| S769 | Phosphorylation | Uniprot | |
| Y942 | Phosphorylation | Uniprot | |
| K1059 | Acetylation | Uniprot | |
| K1070 | Acetylation | Uniprot | |
| K1071 | Acetylation | Uniprot | |
| K1079 | Ubiquitination | Uniprot |
研究背景
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.
Mitochondrion inner membrane>Multi-pass membrane protein>Matrix side.
Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.
Homodimer.
In the N-terminal section; belongs to the AlaDH/PNT family.
In the C-terminal section; belongs to the PNT beta subunit family.
研究領域
· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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