製品: NCR2 Antibody
カタログ: DF9677
タンパク質の説明: Rabbit polyclonal antibody to NCR2
アプリケーション: WB IHC
反応性: Human
分子量: 31 kDa; 31kD(Calculated).
ユニプロット: O95944
RRID: AB_2842873

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
NCR2 Antibody detects endogenous levels of total NCR2.
RRID:
AB_2842873
引用形式: Affinity Biosciences Cat# DF9677, RRID:AB_2842873.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Activating NK receptor NKp44; CD336; CD336 antigen; dJ149M18.1; LY95; Lymphocyte antigen 95 (activating NK receptor; NK p44); Lymphocyte antigen 95 homolog (activating NK receptor; NK p44); Lymphocyte antigen 95 homolog; Lymphocyte antigen 95, mouse, homolog of; Natural cytotoxicity triggering receptor 2; Natural killer cell p44 related protein; Natural killer cell p44-related protein; NCR2; NCTR2_HUMAN; NK cell activating receptor (NKp44); NK cell activating receptor; NK cell-activating receptor; NK p44; NK-p44; NKp44;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
O95944 NCTR2_HUMAN:

Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.

タンパク質配列:
MAWRALHPLLLLLLLFPGSQAQSKAQVLQSVAGQTLTVRCQYPPTGSLYEKKGWCKEASALVCIRLVTSSKPRTMAWTSRFTIWDDPDAGFFTVTMTDLREEDSGHYWCRIYRPSDNSVSKSVRFYLVVSPASASTQTSWTPRDLVSSQTQTQSCVPPTAGARQAPESPSTIPVPSQPQNSTLRPGPAAPIALVPVFCGLLVAKSLVLSALLVWWGDIWWKTMMELRSLDTQKATCHLQQVTDLPWTSVSSPVEREILYHTVARTKISDDDDEHTL

PTMs - O95944 基板として

Site PTM Type Enzyme
S228 Phosphorylation

研究背景

機能:

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.

サブユニット構造:

Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.

タンパク質ファミリー:

Belongs to the natural cytotoxicity receptor (NCR) family.

研究領域

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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