NVL Antibody - #DF9714
| 製品: | NVL Antibody |
| カタログ: | DF9714 |
| タンパク質の説明: | Rabbit polyclonal antibody to NVL |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 95 kDa; 95kD(Calculated). |
| ユニプロット: | O15381 |
| RRID: | AB_2842909 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9714, RRID:AB_2842909.
折りたたみ／展開
Nuclear valosin containing protein like; Nuclear valosin-containing protein-like; Nuclear VCP like; Nuclear VCP-like protein; Nvl; NVL_HUMAN; NVLp; OTTHUMP00000035641; OTTHUMP00000216593; OTTHUMP00000216594; OTTHUMP00000216599; OTTHUMP00000216600;
免疫原
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
- O15381 NVL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
PTMs - O15381 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K12 | Ubiquitination | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| Y29 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K70 | Acetylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| T76 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K129 | Acetylation | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| T178 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| S185 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| K208 | Sumoylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| Y290 | Phosphorylation | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| K498 | Acetylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| Y655 | Phosphorylation | Uniprot | |
| K671 | Ubiquitination | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| S801 | Phosphorylation | Uniprot | |
| S814 | Phosphorylation | Uniprot | |
| K826 | Ubiquitination | Uniprot | |
| S837 | Phosphorylation | Uniprot | |
| S838 | Phosphorylation | Uniprot | |
| S840 | Phosphorylation | Uniprot |
研究背景
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.
Nucleus>Nucleoplasm.
Nucleus>Nucleolus. Nucleus>Nucleoplasm.
Note: Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus.
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
Interacts with NCL/nucleolin. Isoform 1 and isoform 2 interact with TERT and isoform 1 exhibits a higher binding affinity for TERT compared to isoform 2. Isoform 1 interacts with MTREX in an ATP-dependent manner; the interaction is required to associate NVL with nuclear RNA exosome. Isoform 1 interacts with RPL5 in an ATP-dependent manner. Interacts with WDR74 (through WDR repeats); the interaction is independent of RNA or pre-60S ribosome particles.
Belongs to the AAA ATPase family.
研究領域
· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.