PEX6 Antibody - #DF9738
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9738, RRID:AB_2842933.
折りたたみ／展開
PAF 2; PAF2; PBD4A; PDB4B; Peroxin 6; Peroxisomal AAA type ATPase 1; Peroxisomal biogenesis factor 6; Peroxisomal type ATPase 1; Peroxisome assembly factor 2; PXAAA1;
免疫原
Expressed in the retina, at higher levels in the photoreceptor layer at the joint between the outer and inner segments.
- Q13608 PEX6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALAVLRVLEPFPTETPPLAVLLPPGGPWPAAELGLVLALRPAGESPAGPALLVAALEGPDAGTEEQGPGPPQLLVSRALLRLLALGSGAWVRARAVRRPPALGWALLGTSLGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRARLCPESGDSSRPPPPPVVSSFAVSGTVRRLQGVLGGTGDSLGVSRSCLRGLGLFQGEWVWVAQARESSNTSQPHLARVQVLEPRWDLSDRLGPGSGPLGEPLADGLALVPATLAFNLGCDPLEMGELRIQRYLEGSIAPEDKGSCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGSTLSPVPWLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13608 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R93 | Methylation | Uniprot | |
| R95 | Methylation | Uniprot | |
| R119 | Methylation | Uniprot | |
| R161 | Methylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| K714 | Ubiquitination | Uniprot | |
| K715 | Ubiquitination | Uniprot | |
| K750 | Ubiquitination | Uniprot |
研究背景
Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.
Cytoplasm. Peroxisome membrane. Cell projection>Cilium>Photoreceptor outer segment.
Note: Associated with peroxisomal membranes. Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283).
Expressed in the retina, at higher levels in the photoreceptor layer at the joint between the outer and inner segments.
Interacts directly with PEX26 and PEX1. Mediates the indirect interaction between PEX1 and PEX26. Interacts with ZFAND6.
Belongs to the AAA ATPase family.
研究領域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
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