PREX1 Antibody - #DF9740
| 製品: | PREX1 Antibody |
| カタログ: | DF9740 |
| タンパク質の説明: | Rabbit polyclonal antibody to PREX1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 186 kDa; 186kD(Calculated). |
| ユニプロット: | Q8TCU6 |
| RRID: | AB_2842935 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9740, RRID:AB_2842935.
折りたたみ／展開
4; 5)-dependent Rac exchanger 1; KIAA1415; OTTHUMP00000031228; P REX1; P Rex1 protein like; P-Rex1; Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchange factor 1; Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1; Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1 protein; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Prex1; PREX1_HUMAN; PtdIns(3; PtdIns(3,4,5) dependent Rac exchanger 1; SET domain containing 6; Setd6;
免疫原
Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
- Q8TCU6 PREX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8TCU6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S174 | Phosphorylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| T308 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T437 | Phosphorylation | Uniprot | |
| K482 | Ubiquitination | Uniprot | |
| T526 | Phosphorylation | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| S605 | Phosphorylation | Uniprot | |
| K624 | Ubiquitination | Uniprot | |
| K642 | Acetylation | Uniprot | |
| K649 | Ubiquitination | Uniprot | |
| T704 | Phosphorylation | Uniprot | |
| S805 | Phosphorylation | Uniprot | |
| S834 | Phosphorylation | Uniprot | |
| K926 | Ubiquitination | Uniprot | |
| K945 | Ubiquitination | Uniprot | |
| S991 | Phosphorylation | Uniprot | |
| K999 | Sumoylation | Uniprot | |
| S1001 | Phosphorylation | Uniprot | |
| S1049 | Phosphorylation | Uniprot | |
| S1065 | Phosphorylation | Uniprot | |
| K1069 | Ubiquitination | Uniprot | |
| S1125 | Phosphorylation | Uniprot | |
| S1159 | Phosphorylation | Uniprot | |
| S1165 | Phosphorylation | Uniprot | |
| Y1166 | Phosphorylation | Uniprot | |
| S1169 | Phosphorylation | Uniprot | |
| S1179 | Phosphorylation | Uniprot | |
| S1182 | Phosphorylation | Uniprot | |
| S1191 | Phosphorylation | Uniprot | |
| S1195 | Phosphorylation | Uniprot | |
| S1200 | Phosphorylation | Uniprot | |
| R1209 | Methylation | Uniprot | |
| K1249 | Ubiquitination | Uniprot | |
| S1256 | Phosphorylation | Uniprot | |
| S1272 | Phosphorylation | Uniprot | |
| Y1442 | Phosphorylation | Uniprot | |
| K1500 | Ubiquitination | Uniprot | |
| T1525 | Phosphorylation | Uniprot |
研究背景
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Cytoplasm>Cytosol. Cell membrane.
Note: Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Interacts preferentially with RAC2. Interacts with RAC1. Interacts with AUTS2.
研究領域
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
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