INPP5J Antibody - #DF9741
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9741, RRID:AB_2842936.
折りたたみ／展開
5-bisphosphate 5-phosphatase A; Inositol polyphosphate 5-phosphatase; Inositol polyphosphate 5-phosphatase J; INPP5; Inpp5j; Phosphatidylinositol 4; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; PI5PA_HUMAN; PIB5PA; PIPP;
免疫原
- Q15735 PI5PA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRLALAPVGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASAGPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTLAASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDAPAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRPPQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSPCVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15735 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R7 | Methylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| T30 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| R56 | Methylation | Uniprot | |
| R65 | Methylation | Uniprot | |
| R76 | Methylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| R83 | Methylation | Uniprot | |
| T91 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| Y667 | Phosphorylation | Uniprot | |
| S694 | Phosphorylation | Uniprot | |
| S881 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot | |
| S888 | Phosphorylation | Uniprot | |
| S902 | Phosphorylation | Uniprot | |
| S903 | Phosphorylation | Uniprot | |
| S910 | Phosphorylation | Uniprot | |
| S912 | Phosphorylation | Uniprot | |
| S914 | Phosphorylation | Uniprot | |
| S917 | Phosphorylation | Uniprot | |
| S990 | Phosphorylation | Uniprot | |
| S992 | Phosphorylation | Uniprot |
研究背景
Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).
Cytoplasm.
Note: Predominantly localized to membrane ruffles.
The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
研究領域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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