PABPC4 Antibody - #DF9762
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9762, RRID:AB_2842957.
折りたたみ／展開
Activated platelet protein 1; Activated-platelet protein 1; APP 1; APP-1; APP1; FLJ43938; Inducible poly(A) binding protein; Inducible poly(A)-binding protein; iPABP; IPABP4; PABP 4; PABP-4; PABP4; PABP4_HUMAN; PABPC 4; PABPC4; Poly A binding protein cytoplasmic 4; Poly(A) binding protein 4; Poly(A) binding protein cytoplasmic 4 (inducible form); Poly(A) binding protein cytoplasmic 4; Poly(A)-binding protein 4; Polyadenylate binding protein 4; Polyadenylate-binding protein 4; Polyadenylate-binding protein, cytoplasmic, 4; Polyadenylate-binding protein, inducible;
免疫原
Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.
- Q13310 PABP4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13310 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S32 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| Y56 | Phosphorylation | Uniprot | |
| T71 | Phosphorylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| S96 | Phosphorylation | Uniprot | |
| K104 | Acetylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K108 | Acetylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| Y116 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| Y140 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| R166 | Methylation | Uniprot | |
| K167 | Sumoylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| R179 | Methylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| K188 | Methylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| T191 | Phosphorylation | Uniprot | |
| Y194 | Phosphorylation | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| Y291 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| T304 | Phosphorylation | Uniprot | |
| K309 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| T321 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| K361 | Ubiquitination | Uniprot | |
| Y364 | Phosphorylation | Uniprot | |
| K375 | Methylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| T379 | Phosphorylation | Uniprot | |
| Y382 | Phosphorylation | Uniprot | |
| R385 | Methylation | Uniprot | |
| R419 | Methylation | Uniprot | |
| R432 | Methylation | Uniprot | |
| R436 | Methylation | Uniprot | |
| R442 | Methylation | Uniprot | |
| R454 | Methylation | Uniprot | |
| R459 | Methylation | Uniprot | |
| R463 | Methylation | Uniprot | |
| R509 | Methylation | Uniprot | |
| R518 | Methylation | Uniprot | |
| K524 | Methylation | Uniprot | |
| R530 | Methylation | Uniprot | |
| S531 | Phosphorylation | Uniprot | |
| S584 | Phosphorylation | Uniprot | |
| S600 | Phosphorylation | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| K629 | Ubiquitination | Uniprot | |
| K635 | Ubiquitination | Uniprot | |
| S644 | Phosphorylation | Uniprot |
研究背景
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
Arg-518 is dimethylated, probably to asymmetric dimethylarginine.
Cytoplasm.
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1. Interacts with ZFC3H1 in a RNase-sensitive manner.
Belongs to the polyadenylate-binding protein type-1 family.
研究領域
· Genetic Information Processing > Translation > RNA transport.
· Genetic Information Processing > Translation > mRNA surveillance pathway.
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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