PPP1R3D Antibody - #DF9780
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9780, RRID:AB_2842975.
折りたたみ／展開
PP1 subunit R6; PPP1R3D; PPP1R6; PPR3D_HUMAN; Protein phosphatase 1 regulatory subunit 3D; Protein phosphatase 1 regulatory subunit 6; Protein phosphatase 1-binding subunit R6;
免疫原
- O95685 PPR3D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRGPSSAVLPSALGSRKLGPRSLSCLSDLDGGVALEPRACRPPGSPGRAPPPTPAPSGCDPRLRPIILRRARSLPSSPERRQKAAGAPGAACRPGCSQKLRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLHCLVPDFPPPVEAADFGERLQRQLVCLERVTCSDLGISGTVRVCNVAFEKQVAVRYTFSGWRSTHEAVARWRGPAGPEGTEDVFTFGFPVPPFLLELGSRVHFAVRYQVAGAEYWDNNDHRDYSLTCRNHALHMPRGECEESWIHFI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95685 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R3 | Methylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| T54 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| S133 | Phosphorylation | Uniprot |
研究背景
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
Expressed in all tissues tested. High expression in skeletal muscle and heart.
Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen. Interacts with EPM2A; in the presence of NHLC1/malin the interaction leads to PPP1R3D ubiquitination and autophagic degradation.
The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.