REPS2 Antibody - #DF9801
| 製品: | REPS2 Antibody |
| カタログ: | DF9801 |
| タンパク質の説明: | Rabbit polyclonal antibody to REPS2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 72 kDa; 72kD(Calculated). |
| ユニプロット: | Q8NFH8 |
| RRID: | AB_2842995 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9801, RRID:AB_2842995.
折りたたみ／展開
OTTHUMP00000022995; Partner of Ral binding protein 1; Partner of RalBP1; POB1; RALBP1 associated Eps domain containing 2; RALBP1 interacting protein 2; RALBP1-associated Eps domain-containing protein 2; REPS 2;
免疫原
Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.
- Q8NFH8 REPS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKDVLYSQPPSKPIRRKFRPENQATENQEPSTAASGPASAATMKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8NFH8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y103 | Phosphorylation | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| Y212 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| T446 | Phosphorylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| Y462 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S464 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| T479 | Phosphorylation | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| S544 | Phosphorylation | Uniprot | |
| Y558 | Phosphorylation | Uniprot | |
| S563 | Phosphorylation | Uniprot | |
| K610 | Acetylation | Uniprot | |
| S631 | Phosphorylation | Uniprot |
研究背景
Involved in growth factor signaling through its influence on the Ral signaling pathway.
EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2.
Cytoplasm.
Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.
Interacts with ASAP1 and this complex can bind paxillin. May form a ternary complex with RALBP1 and ASAP1 (By similarity). Interacts with RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. It can form a ternary complex with activated Ral and RALBP1. Binds EPN1.
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