RASA4 Antibody - #DF9805
| 製品: | RASA4 Antibody |
| カタログ: | DF9805 |
| タンパク質の説明: | Rabbit polyclonal antibody to RASA4 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Zebrafish, Chicken, Xenopus |
| 分子量: | 90 kDa; 90kD(Calculated). |
| ユニプロット: | O43374 |
| RRID: | AB_2842999 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9805, RRID:AB_2842999.
折りたたみ／展開
Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; CAPRI; GAPL; GTPase activating protein like; KIAA0538; MGC131890; Ras GTPase activating protein 4; RAS p21 protein activator 4; RasGAP activating like protein 2;
免疫原
- O43374 RASL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O43374 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K33 | Ubiquitination | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| S96 | Phosphorylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| Y381 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| S476 | Phosphorylation | Uniprot | |
| S481 | Phosphorylation | Uniprot | |
| K505 | Ubiquitination | Uniprot | |
| T515 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| K569 | Ubiquitination | Uniprot | |
| S595 | Phosphorylation | Uniprot | |
| S760 | Phosphorylation | Uniprot |
研究背景
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Cytoplasm>Cytosol. Cell membrane>Peripheral membrane protein.
Note: Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
Widely expressed.
The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
研究領域
· Environmental Information Processing > Signal transduction > Ras signaling pathway. (View pathway)
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