PTPRB Antibody - #DF9841
| 製品: | PTPRB Antibody |
| カタログ: | DF9841 |
| タンパク質の説明: | Rabbit polyclonal antibody to PTPRB |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Rabbit |
| 分子量: | 224kDa; 224kD(Calculated). |
| ユニプロット: | P23467 |
| RRID: | AB_2843035 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9841, RRID:AB_2843035.
折りたたみ／展開
HPTP BETA; HPTPB; Phosphacan receptor type B; Protein tyrosine phosphatase receptor type B; Protein-tyrosine phosphatase beta; PTPB; Ptprb; PTPRB_HUMAN; R PTP BETA; R-PTP-beta; Receptor-type tyrosine-protein phosphatase beta; RPTPB; Vascular endothelial protein tyrosine phosphatase; VE-PTP;
免疫原
- P23467 PTPRB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P23467 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| T62 | Phosphorylation | Uniprot | |
| T201 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| T465 | Phosphorylation | Uniprot | |
| Y531 | Phosphorylation | Uniprot | |
| T534 | Phosphorylation | Uniprot | |
| S537 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| T605 | Phosphorylation | Uniprot | |
| S606 | Phosphorylation | Uniprot | |
| S698 | Phosphorylation | Uniprot | |
| S701 | Phosphorylation | Uniprot | |
| T709 | Phosphorylation | Uniprot | |
| T711 | Phosphorylation | Uniprot | |
| Y719 | Phosphorylation | Uniprot | |
| S723 | Phosphorylation | Uniprot | |
| S725 | Phosphorylation | Uniprot | |
| S1008 | Phosphorylation | Uniprot | |
| T1067 | Phosphorylation | Uniprot | |
| S1069 | Phosphorylation | Uniprot | |
| S1195 | Phosphorylation | Uniprot | |
| Y1209 | Phosphorylation | Uniprot | |
| S1314 | Phosphorylation | Uniprot | |
| Y1320 | Phosphorylation | Uniprot | |
| Y1328 | Phosphorylation | Uniprot | |
| S1647 | Phosphorylation | Uniprot | |
| S1666 | Phosphorylation | Uniprot | |
| K1705 | Ubiquitination | Uniprot | |
| Y1733 | Phosphorylation | Uniprot | |
| Y1739 | Phosphorylation | Uniprot | |
| T1742 | Phosphorylation | Uniprot | |
| Y1953 | Phosphorylation | Uniprot | |
| Y1955 | Phosphorylation | Uniprot | |
| Y1981 | Phosphorylation | Uniprot | |
| Y1988 | Phosphorylation | Uniprot | |
| Y1994 | Phosphorylation | Uniprot |
研究背景
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Membrane>Single-pass type I membrane protein.
Monomer. Interacts with TEK. Interacts via fibronectin type-III 17 domain with CDH5. Detected in a complex with CNTN1 and NRCAM (By similarity). Interacts (phosphorylated form) with FYN and GRB2 (By similarity).
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
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