SEPT5 Antibody - #DF9881
| 製品: | SEPT5 Antibody |
| カタログ: | DF9881 |
| タンパク質の説明: | Rabbit polyclonal antibody to SEPT5 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Dog, Chicken, Xenopus |
| 分子量: | 43 kDa; 43kD(Calculated). |
| ユニプロット: | Q99719 |
| RRID: | AB_2843075 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9881, RRID:AB_2843075.
折りたたみ／展開
5 Sep; CDCrel 1; CDCREL; CDCrel-1; CDCREL1; Cell division control related protein 1; Cell division control-related protein 1; H5; HCDCREL 1; OTTHUMP00000197271; OTTHUMP00000197272; OTTHUMP00000197273; OTTHUMP00000197274; OTTHUMP00000197275; OTTHUMP00000197276; OTTHUMP00000197396; OTTHUMP00000197410; Peanut like 1; Peanut like 1 homolog; Peanut like protein 1; Peanut-like protein 1; Platelet glycoprotein Ib beta chain; PNUTL1; SEPT5; SEPT5_HUMAN; Septin 5; Septin-5;
免疫原
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
- Q99719 SEPT5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q99719 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R6 | Methylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| T29 | Phosphorylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| T251 | Phosphorylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| T341 | Phosphorylation | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K363 | Methylation | Uniprot |
研究背景
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).
In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.
Cytoplasm. Cytoplasm>Cytoskeleton.
Note: In platelets, found in areas surrounding alpha-granules.
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPTIN2 and SEPTIN5. In platelets, associated with a complex containing STX4. Interacts with PRKN. This interaction leads to SEPTIN5 ubiquitination and degradation (By similarity).
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
研究領域
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.