製品: STK38L Antibody
カタログ: DF9885
タンパク質の説明: Rabbit polyclonal antibody to STK38L
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 50-60kD; 54kD(Calculated).
ユニプロット: Q9Y2H1
RRID: AB_2843079

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(92%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(83%)
クローナリティ:
Polyclonal
特異性:
STK38L Antibody detects endogenous levels of total STK38L.
RRID:
AB_2843079
引用形式: Affinity Biosciences Cat# DF9885, RRID:AB_2843079.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

KIAA0965; NDR2; NDR2 protein kinase; nuclear Dbf2 related 2; Nuclear Dbf2 related kinase 2; Nuclear Dbf2-related kinase 2; Serine/threonine protein kinase 38 like; Serine/threonine-protein kinase 38-like; ST38L_HUMAN; Stk38l;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q9Y2H1 ST38L_HUMAN:

Ubiquitously expressed with highest levels observed in the thymus.

タンパク質配列:
MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Pig
92
Xenopus
83
Zebrafish
75
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9Y2H1 基板として

Site PTM Type Enzyme
K73 Ubiquitination
T75 Phosphorylation
K94 Ubiquitination
K110 Ubiquitination
Y116 Phosphorylation
K119 Ubiquitination
K123 Ubiquitination
K129 Ubiquitination
K215 Ubiquitination
K224 Ubiquitination
K228 Ubiquitination
T236 Phosphorylation
K239 Ubiquitination
S265 Phosphorylation
K266 Ubiquitination
S282 Phosphorylation Q9Y2H1 (STK38L)
T283 Phosphorylation
T286 Phosphorylation
Y289 Phosphorylation
K355 Ubiquitination
K378 Ubiquitination
K403 Ubiquitination
Y441 Phosphorylation
T442 Phosphorylation Q9Y6E0 (STK24)
Y443 Phosphorylation
T450 Phosphorylation
R452 Methylation
S454 Phosphorylation
K460 Ubiquitination

PTMs - Q9Y2H1 酵素として

Substrate Site Source
O60285 (NUAK1) T211 Uniprot
P46937 (YAP1) S127 Uniprot
Q96QF0 (RAB3IP) S288 Uniprot
Q9Y2H1 (STK38L) S282 Uniprot

研究背景

機能:

Involved in the regulation of structural processes in differentiating and mature neuronal cells.

細胞の位置付け:

Cytoplasm. Cytoplasm>Cytoskeleton. Membrane.
Note: Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitously expressed with highest levels observed in the thymus.

サブユニット構造:

Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.

タンパク質ファミリー:

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

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