SERPINB10 Antibody - #DF9894

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製品: SERPINB10 Antibody
カタログ: DF9894
タンパク質の説明: Rabbit polyclonal antibody to SERPINB10
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Horse, Rabbit, Dog
分子量: 45 kDa; 45kD(Calculated).
ユニプロット: P48595
RRID: AB_2843088

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(91%), Horse(91%), Rabbit(91%), Dog(82%)
クローナリティ:
Polyclonal
特異性:
SERPINB10 Antibody detects endogenous levels of total SERPINB10.
RRID:
AB_2843088
引用形式: Affinity Biosciences Cat# DF9894, RRID:AB_2843088.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Bomapin; Peptidase inhibitor 10; PI-10; PI10; Protease inhibitor 10; Protease inhibitor 10 (ovalbumin type bomapin); Serpin B10; Serpin peptidase inhibitor clade B (ovalbumin) member 10; SERPINB10; SPB10_HUMAN;

免疫原

免疫原:
Uniprot:

P48595(SPB10_HUMAN) >>Visit HPA database.

遺伝子(ID):
SERPINB10(5273)
発現特異性:
P48595 SPB10_HUMAN:

Expressed specifically in myeloid cells and the bone marrow.

タンパク質配列:
MDSLATSINQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVKCDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQFLVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGMSSARNLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPSIEFNANHPFLFFIRHNKTNTILFYGRLCSP

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
91
Horse
91
Rabbit
91
Dog
82
Bovine
73
Sheep
73
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P48595 基板として

Site PTM Type Enzyme
S307 Phosphorylation
S318 Phosphorylation

研究背景

機能:

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

細胞の位置付け:

Nucleus. Cytoplasm.
Note: Mostly found in the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed specifically in myeloid cells and the bone marrow.

タンパク質ファミリー:

Belongs to the serpin family. Ov-serpin subfamily.

研究領域

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

参考文献

1). Proteomic analyses reveal higher levels of neutrophil activation in men than in women with systemic lupus erythematosus. Frontiers in Immunology, 2022 (PubMed: 35799787) [IF=7.3]

Application: WB    Species: Human    Sample:

Figure 6 Western Blot Validation of Proteins in Neutrophil Activation Networks. (A) Western blot analysis of BST2, PGAM1 and SERPINB10 in male SLE and female SLE. (B) Boxplot showing gray value of BST2 in male SLE and female SLE. (C) Boxplot showing gray value of PGAM1 in male SLE and female SLE. (D) Boxplot showing gray value of SERPINB10 in male SLE and female SLE.
2). Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway. Antioxidants, 2023 (PubMed: 36829992) [IF=7.0]

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