SH2B3 Antibody - #DF9898
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9898, RRID:AB_2843092.
折りたたみ／展開
IDDM20; Lymphocyte adapter protein; Lymphocyte specific adapter protein; Lymphocyte specific adapter protein Lnk; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; SH2B adaptor protein 3; Sh2b3; SH2B3_HUMAN; Signal transduction protein Lnk;
免疫原
- Q9UQQ2 SH2B3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
PTMs - Q9UQQ2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| T159 | Phosphorylation | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| Y203 | Phosphorylation | Uniprot | |
| Y273 | Phosphorylation | P43403 (ZAP70) , P06239 (LCK) | Uniprot |
| S330 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| S511 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| Y555 | Phosphorylation | Uniprot | |
| S559 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| Y572 | Phosphorylation | Uniprot |
研究背景
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Tyrosine phosphorylated by LCK.
Preferentially expressed by lymphoid cell lines.
Binds to the tyrosine-phosphorylated TCR zeta chain via its SH2 domain.
Belongs to the SH2B adapter family.
研究領域
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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