製品: STMN2 Antibody
カタログ: DF9949
タンパク質の説明: Rabbit polyclonal antibody to STMN2
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 21 kDa; 21kD(Calculated).
ユニプロット: Q93045
RRID: AB_2843143

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
STMN2 Antibody detects endogenous levels of total STMN2.
RRID:
AB_2843143
引用形式: Affinity Biosciences Cat# DF9949, RRID:AB_2843143.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Neuron specific growth associated protein; Neuronal growth associated protein; Neuronal growth associated protein (silencer element); Protein SCG10; SCG 10; SCG10; SCG10 protein; SCGN 10; SCGN10; SGC 10; SGC10; Stathmin 2; Stathmin like 2; Stathmin-2; STMN 2; STMN2; STMN2_HUMAN; Superior cervical ganglia neural specific 10; Superior cervical ganglion 10 protein; Superior cervical ganglion-10 protein; Superiorcervical ganglia neural specific 10;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q93045 STMN2_HUMAN:

Neuron specific.

タンパク質配列:
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q93045 基板として

Site PTM Type Enzyme
Y35 Phosphorylation
S50 Phosphorylation O96013 (PAK4)
S62 Phosphorylation P45983 (MAPK8) , P53779 (MAPK10) , P27361 (MAPK3)
S73 Phosphorylation P53779 (MAPK10) , P27361 (MAPK3) , P45983 (MAPK8)
K77 Ubiquitination
S80 Phosphorylation
K86 Acetylation
K86 Ubiquitination
K87 Acetylation
K87 Ubiquitination
S97 Phosphorylation
K119 Acetylation
K119 Ubiquitination
S128 Phosphorylation
K129 Acetylation
K129 Ubiquitination

研究背景

機能:

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).

PTMs:

Sumoylated.

Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.

細胞の位置付け:

Cytoplasm. Cytoplasm>Perinuclear region. Cell projection>Growth cone. Membrane>Peripheral membrane protein>Cytoplasmic side. Cell projection>Axon. Golgi apparatus. Endosome. Cell projection>Lamellipodium.
Note: Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Neuron specific.

サブユニット構造:

Interacts with MAPK8 (By similarity). Interacts with ITM2C. Interacts with KIFBP. Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2.

タンパク質ファミリー:

Belongs to the stathmin family.

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