SART1 Antibody - #DF9978
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9978, RRID:AB_2843170.
折りたたみ／展開
Ara 1; ARA1; HOMS 1; HOMS1; hSART 1; hSART1; hSnu 66; hSnu66; IgE autoantigen; MGC2038; SART 1; SART1 259; SART1(259) protein; SART1(800) protein; SART1259; Snu 66; Snu66; Squamous cell carcinoma antigen recognised by T cells; Squamous cell carcinoma antigen recognized by T cells 1; U4/U6.U5 tri snRNP associated 110 kDa protein; U4/U6.U5 tri snRNP associated protein 1;
免疫原
- O43290 SNUT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSMNANTITK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O43290 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T22 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| K94 | Sumoylation | Uniprot | |
| Y102 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K133 | Acetylation | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| K141 | Sumoylation | Uniprot | |
| K147 | Sumoylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K188 | Sumoylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| T189 | Phosphorylation | Uniprot | |
| T200 | Phosphorylation | Uniprot | |
| Y249 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| T271 | Phosphorylation | Uniprot | |
| T275 | Phosphorylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| Y316 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| R385 | Methylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| Y390 | Phosphorylation | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| T466 | Phosphorylation | Uniprot | |
| S474 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| S521 | Phosphorylation | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| K530 | Ubiquitination | Uniprot | |
| S591 | Phosphorylation | Uniprot | |
| S596 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| S623 | Phosphorylation | Uniprot | |
| K648 | Ubiquitination | Uniprot | |
| K657 | Ubiquitination | Uniprot | |
| K666 | Ubiquitination | Uniprot | |
| S667 | Phosphorylation | Uniprot | |
| Y673 | Phosphorylation | Uniprot | |
| K678 | Ubiquitination | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| Y685 | Phosphorylation | Uniprot | |
| S686 | Phosphorylation | Uniprot | |
| R692 | Methylation | Uniprot | |
| T695 | Phosphorylation | Uniprot | |
| K699 | Ubiquitination | Uniprot | |
| K709 | Sumoylation | Uniprot | |
| Y712 | Phosphorylation | Uniprot | |
| K719 | Ubiquitination | Uniprot | |
| T721 | Phosphorylation | Uniprot | |
| K723 | Ubiquitination | Uniprot | |
| S730 | Phosphorylation | Uniprot | |
| K742 | Sumoylation | Uniprot | |
| K749 | Ubiquitination | Uniprot | |
| K757 | Methylation | Uniprot | |
| K758 | Methylation | Uniprot | |
| K758 | Sumoylation | Uniprot | |
| K758 | Ubiquitination | Uniprot | |
| S760 | Phosphorylation | Uniprot | |
| S761 | Phosphorylation | Uniprot | |
| S762 | Phosphorylation | Uniprot | |
| T764 | Phosphorylation | Uniprot | |
| T768 | Phosphorylation | Uniprot | |
| K775 | Ubiquitination | Uniprot | |
| T781 | Phosphorylation | Uniprot | |
| Y783 | Phosphorylation | Uniprot | |
| S789 | Phosphorylation | Uniprot |
研究背景
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
Sumoylated with SUMO2.
Nucleus.
Note: Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.
Ubiquitously expressed.
Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39.
Belongs to the SNU66/SART1 family.
研究領域
· Genetic Information Processing > Transcription > Spliceosome.
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