UBE4A Antibody - #DF9996
| 製品: | UBE4A Antibody |
| カタログ: | DF9996 |
| タンパク質の説明: | Rabbit polyclonal antibody to UBE4A |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 123 kDa; 123kD(Calculated). |
| ユニプロット: | Q14139 |
| RRID: | AB_2843188 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9996, RRID:AB_2843188.
折りたたみ／展開
E4; KIAA0126; MGC133315; UBE4A; UBE4A_HUMAN; Ubiquitin conjugation factor E4 A; ubiquitination factor E4A (UFD2 homolog yeast); Ubiquitination factor E4A; UBOX2; UFD2; UFD2 homolog; UFD2b;
免疫原
- Q14139 UBE4A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVAEISRSFRSQQEICEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQALFARLLLQDPGNHLINMTSSTTLNLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALILDEEVRTFPEVMIPVFDILLGRIKDLELCQILLYAYLDILLYFTRQKDMAKVFVEYIQPKDPTNGQMYQKTLLGVILSISCLLKTPGVVENHGYFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILSWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCALKELNDEERKIKNVHMRGLDKETCLIPAVQEPKFPQNYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELTFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFADDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPNPLVSSVFHRKRVFCNFQYAPQLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDTYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFLLDEAIQYLSKIKIQQIEKDRGEWDSLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLAFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIMAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQLE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14139 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| K386 | Acetylation | Uniprot | |
| K451 | Ubiquitination | Uniprot | |
| Y464 | Phosphorylation | Uniprot | |
| C465 | S-Nitrosylation | Uniprot | |
| K468 | Ubiquitination | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| K531 | Acetylation | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| Y749 | Phosphorylation | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| K774 | Ubiquitination | Uniprot | |
| K810 | Ubiquitination | Uniprot | |
| K816 | Ubiquitination | Uniprot | |
| K832 | Ubiquitination | Uniprot | |
| S940 | Phosphorylation | Uniprot |
研究背景
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Cytoplasm.
The U-box domain is required for the ubiquitin protein ligase activity.
Belongs to the ubiquitin conjugation factor E4 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis. (View pathway)
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