Casein Kinase Igamma2 Antibody - #AF9034
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9034, RRID:AB_2843225.
折りたたみ／展開
Casein kinase 1 gamma 2; Casein kinase I isoform gamma 1; Casein kinase I isoform gamma 3; Casein kinase I isoform gamma-2; CK1g2; CKI gamma 1; CKI gamma 2; CKI gamma 3; CSNK1G1; CSNK1G2; CSNK1G3;
免疫原
- P78368 KC1G2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P78368 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R25 | Methylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| T35 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| Y71 | Phosphorylation | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| Y93 | Phosphorylation | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| T141 | Phosphorylation | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| Y195 | Phosphorylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| K310 | Ubiquitination | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| T367 | Phosphorylation | Uniprot | |
| T377 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| K404 | Ubiquitination | Uniprot | |
| S410 | Phosphorylation | Uniprot |
PTMs - P78368 酵素として
研究背景
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Autophosphorylated.
Cytoplasm.
Testis.
Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
研究領域
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
Restrictive clause
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