CMTM4 Antibody - #AF9042
| 製品: | CMTM4 Antibody |
| カタログ: | AF9042 |
| タンパク質の説明: | Rabbit polyclonal antibody to CMTM4 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Zebrafish, Bovine, Chicken |
| 分子量: | 25kDa; 26kD(Calculated). |
| ユニプロット: | Q8IZR5 |
| RRID: | AB_2843233 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9042, RRID:AB_2843233.
折りたたみ／展開
Chemokine like factor super family 4; Chemokine-like factor superfamily member 4; CKLF-like MARVEL transmembrane domain containing 4; CKLF4; CKLFSF4; CMTM4;
免疫原
- Q8IZR5 CKLF4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IZR5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S25 | Phosphorylation | Uniprot | |
| Y27 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| Y187 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| T208 | Phosphorylation | Uniprot |
研究背景
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Membrane>Multi-pass membrane protein.
Highly expressed in testis and prostate.
Interacts with PD-L1/CD274 and CMTM6.
Belongs to the chemokine-like factor family.
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