CNOT2 Antibody - #AF9043
| 製品: | CNOT2 Antibody |
| カタログ: | AF9043 |
| タンパク質の説明: | Rabbit polyclonal antibody to CNOT2 |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 46kDa; 60kD(Calculated). |
| ユニプロット: | Q9NZN8 |
| RRID: | AB_2843234 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9043, RRID:AB_2843234.
折りたたみ／展開
CCR4 associated factor 2; CCR4 NOT transcription complex subunit 2; CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CDC36; CNOT2; CNOT2_HUMAN; HSPC131; MSTP046; Negative regulator of transcription 2; NOT2 (negative regulator of transcription 2 yeast) homolog; NOT2; NOT2H;
免疫原
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
- Q9NZN8 CNOT2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NZN8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K12 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| Y37 | Phosphorylation | Uniprot | |
| Y43 | Phosphorylation | Uniprot | |
| Y44 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K56 | Acetylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| R87 | Methylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Q13535 (ATR) | Uniprot |
| T104 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T111 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| R137 | Methylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| T155 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| T304 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| T308 | Phosphorylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| S391 | Phosphorylation | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| Y471 | Phosphorylation | Uniprot | |
| T480 | Phosphorylation | Uniprot | |
| K490 | Ubiquitination | Uniprot | |
| Y494 | Phosphorylation | Uniprot | |
| Y500 | Phosphorylation | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| K520 | Ubiquitination | Uniprot |
研究背景
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
Cytoplasm. Nucleus.
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.
Belongs to the CNOT2/3/5 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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