製品: DCL-1 Antibody
カタログ: AF9052
タンパク質の説明: Rabbit polyclonal antibody to DCL-1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
予測: Pig, Horse, Rabbit, Xenopus
分子量: 26,35kDa; 26kD(Calculated).
ユニプロット: Q8IX05
RRID: AB_2843243

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(100%), Horse(100%), Rabbit(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
DCL-1 Antibody detects endogenous levels of total DCL-1.
RRID:
AB_2843243
引用形式: Affinity Biosciences Cat# AF9052, RRID:AB_2843243.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

BIMLEC; C type lectin BIMLEC; C type lectin domain family 13 member A; C-type lectin BIMLEC; C-type lectin domain family 13 member A; CD302; CD302 antigen; CD302_HUMAN; CLEC13A; DCL1; KIAA0022; Type I transmembrane C type lectin receptor DCL-1; Type I transmembrane C-type lectin receptor DCL-1;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q8IX05 CD302_HUMAN:

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

タンパク質配列:
MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASFKWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNHILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Xenopus
100
Rabbit
100
Bovine
75
Sheep
0
Dog
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8IX05 基板として

Site PTM Type Enzyme
S101 Phosphorylation
K140 Methylation

研究背景

機能:

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.

PTMs:

May be heterogeneously N-glycosylated in some cell types.

細胞の位置付け:

Membrane>Single-pass type I membrane protein. Cell projection>Filopodium. Cytoplasm>Cell cortex. Cell projection>Microvillus.
Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

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