DNA pol lambda Antibody - #AF9055
| 製品: | DNA pol lambda Antibody |
| カタログ: | AF9055 |
| タンパク質の説明: | Rabbit polyclonal antibody to DNA pol lambda |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 63kDa; 63kD(Calculated). |
| ユニプロット: | Q9UGP5 |
| RRID: | AB_2843246 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9055, RRID:AB_2843246.
折りたたみ／展開
BETA N; BETAN; DNA directed DNA polymerase lambda; DNA polymerase beta 2; DNA polymerase beta-2; DNA polymerase kappa; DNA polymerase kappa DNA polymerase beta N; DNA polymerase lambda; DNA polymerase lamda2; DPOLL_HUMAN; EC 2.7.7.7,EC 4.2.99.; FLJ46002; OTTHUMP00000020321; OTTHUMP00000020323; OTTHUMP00000059179; Pol beta2; POL KAPPA; Pol Lambda; POLKAPPA; POLL; Polymerase DNA directed lambda;
免疫原
- Q9UGP5 DPOLL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UGP5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K23 | Ubiquitination | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T173 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T204 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S246 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| Y380 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| T553 | Phosphorylation | P24941 (CDK2) | Uniprot |
研究背景
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Nucleus.
Expressed in a number of tissues. Abundant in testis.
Binds PCNA.
Belongs to the DNA polymerase type-X family.
研究領域
· Genetic Information Processing > Replication and repair > Base excision repair.
· Genetic Information Processing > Replication and repair > Non-homologous end-joining.
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