Ephrin-B3 Antibody - #AF9060
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9060, RRID:AB_2843251.
折りたたみ／展開
EFL 6; EFL6; EFNB 3; Efnb3; EFNB3_HUMAN; EPH related receptor transmembrane ligand ELK L3; EPH related receptor transmembrane ligand ELKL3; EPH related receptor tyrosine kinase ligand 8; EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; Ephrin B3; Ephrin-B3; EphrinB3; EPLG 8; EPLG8; LERK 8; LERK-8; LERK8;
免疫原
Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
- Q15768 EFNB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGPPHSGPGGVRVGALLLLGVLGLVSGLSLEPVYWNSANKRFQAEGGYVLYPQIGDRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGRRCEAPPAPNLLLTCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRGMKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSLEPGKENLPGDPTSNATSRGAEGPLPPPSMPAVAGAAGGLALLLLGVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLGLGGGGGMGPREAEPGELGIALRGGGAADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPPNIYYKV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15768 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S268 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| Y318 | Phosphorylation | Uniprot | |
| Y323 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| Y338 | Phosphorylation | Uniprot |
研究背景
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
(Microbial infection) Acts as a receptor for nipah virus and hendra virus.
Membrane>Single-pass type I membrane protein.
Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
Interacts with GRIP1 and GRIP2.
(Microbial infection) Interacts with nipah virus and hendra virus glycoprotein.
Belongs to the ephrin family.
研究領域
· Organismal Systems > Development > Axon guidance. (View pathway)
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