GS28 Antibody - #AF9082
| 製品: | GS28 Antibody |
| カタログ: | AF9082 |
| タンパク質の説明: | Rabbit polyclonal antibody to GS28 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 37kDa; 29kD(Calculated). |
| ユニプロット: | O95249 |
| RRID: | AB_2843273 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9082, RRID:AB_2843273.
折りたたみ／展開
28 kDa cis Golgi SNARE p28; 28 kDa Golgi SNARE protein; cis-golgi SNARE; golgi integral membrane protein 2; Golgi SNAP receptor complex member 1; Golgi SNARE 28 kDa; GOLIM2; GOS28; GOS28/P28; GOSR1; GS25; Gs28; P28;
免疫原
- O95249 GOSR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95249 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| Y37 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| K124 | Acetylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| Y149 | Phosphorylation | Uniprot | |
| K150 | Methylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| T160 | Phosphorylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| S217 | Phosphorylation | Uniprot |
研究背景
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
Golgi apparatus membrane>Single-pass type IV membrane protein.
Note: Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius).
Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).
Belongs to the GOSR1 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.
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