IL13 receptor alpha 1 Antibody - #AF9095
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9095, RRID:AB_2843286.
折りたたみ／展開
bB128O4.2.1 (interleukin 13 receptor, alpha 1); Cancer/testis antigen 19; CD213a1; CD213A1 Antigen; CT 19; CT19; I13R1_HUMAN; IL 13 receptor subunit alpha 1; IL 13R alpha 1; IL 13R subunit alpha 1; IL 13Ra; IL 13RA1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; IL13 receptor alpha 1 chain; IL13R; IL13RA; Il13ra1; Interleukin 13 receptor alpha 1; Interleukin 13 receptor alpha 1 chain; interleukin 13 receptor subunit alpha 1; Interleukin-13 receptor subunit alpha-1; NR 4; NR4;
免疫原
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
- P78552 I13R1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P78552 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T82 | Phosphorylation | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| Y402 | Phosphorylation | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| K410 | Ubiquitination | Uniprot | |
| T413 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| K423 | Ubiquitination | Uniprot |
研究背景
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Membrane>Single-pass type I membrane protein.
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 5 subfamily.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
参考文献
Application: IHC Species: Mouse Sample: nasal mucosal tissues
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