InsP5 2-kinase Antibody - #AF9097
| 製品: | InsP5 2-kinase Antibody |
| カタログ: | AF9097 |
| タンパク質の説明: | Rabbit polyclonal antibody to InsP5 2-kinase |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 56kDa; 56kD(Calculated). |
| ユニプロット: | Q9H8X2 |
| RRID: | AB_2843288 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9097, RRID:AB_2843288.
折りたたみ／展開
3; 4; 5; 6)P5 2-kinase; 6-pentakisphosphate 2-kinase; bA476B13.1 (novel protein); bA476B13.1; C9orf12; inositol 1,3,4,5,6 pentakisphosphate 2 kinase; Inositol pentakisphosphate 2 kinase; Inositol-1; Inositol-pentakisphosphate 2-kinase; Ins; Ins(1; Ins(1,3,4,5,6)P5 2 kinase; InsP5 2 kinase; InsP5 2-kinase; INSP5K2; IP5K; IPK1; IPK1 homolog; IPPK; IPPK_HUMAN;
免疫原
Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
- Q9H8X2 IPPK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H8X2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K173 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| K198 | Methylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| K357 | Ubiquitination | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K490 | Ubiquitination | Uniprot |
研究背景
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
Cytoplasm. Nucleus.
Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Belongs to the IPK1 type 2 family.
研究領域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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