NDUFS5 Antibody - #AF9124
| 製品: | NDUFS5 Antibody |
| カタログ: | AF9124 |
| タンパク質の説明: | Rabbit polyclonal antibody to NDUFS5 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Rat |
| 予測: | Pig, Zebrafish, Rabbit |
| 分子量: | 15kDa; 13kD(Calculated). |
| ユニプロット: | O43920 |
| RRID: | AB_2843314 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9124, RRID:AB_2843314.
折りたたみ／展開
CI 15k; CI-15 kDa; CI15K; Complex I-15 kDa; NADH dehydrogenase (ubiquinone) Fe S protein 5, 15kDa (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; NADH-ubiquinone oxidoreductase 15 kDa subunit; NADH:ubiquinone oxidoreductase 15 kDa IP subunit; NDUFS5; NDUS5_HUMAN;
免疫原
- O43920 NDUS5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O43920 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Ubiquitination | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K91 | Sumoylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K101 | Ubiquitination | Uniprot |
研究背景
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Mitochondrion inner membrane>Peripheral membrane protein. Mitochondrion intermembrane space.
Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
Belongs to the complex I NDUFS5 subunit family.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
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