Rab11B Antibody - #AF9173
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9173, RRID:AB_2843363.
折りたたみ／展開
GTP-binding protein ypt3; H YPT3; RAB11B; RAB11B member RAS oncogene family; Ras-related protein Rab-11B; RB11B_HUMAN; YPT3;
免疫原
- Q15907 RB11B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15907 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| Y8 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| K24 | Methylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| T43 | Phosphorylation | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| Y73 | Phosphorylation | Uniprot | |
| R74 | Methylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| R104 | Methylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| R132 | Methylation | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| T170 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot |
研究背景
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
Citrullinated by PADI4.
Recycling endosome membrane>Lipid-anchor>Cytoplasmic side. Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle membrane>Lipid-anchor>Cytoplasmic side. Cytoplasmic vesicle>Phagosome membrane>Lipid-anchor>Cytoplasmic side.
Note: Recruited to phagosomes containing S.aureus.
Interacts with KCNMA1 (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with ATP6V1E1. Interacts with PI4KB. Interacts (GDP-bound form) with ZFYVE27. Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner. Interacts with RELCH (By similarity). Interacts (in GTP-bound form) with TBC1D8B (via domain Rab-GAP TBC).
Belongs to the small GTPase superfamily. Rab family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.