Septin 8 Antibody - #AF9197
| 製品: | Septin 8 Antibody |
| カタログ: | AF9197 |
| タンパク質の説明: | Rabbit polyclonal antibody to Septin 8 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 50kDa; 56kD(Calculated). |
| ユニプロット: | Q92599 |
| RRID: | AB_2843387 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF9197, RRID:AB_2843387.
折りたたみ／展開
KIAA0202; OTTHUMP00000211755; SEP 2; SEP2; SEPT 8; SEPT8; Septin8;
免疫原
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.
- Q92599 SEPT8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATDLERFSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKRKVEEKRRELEEETNAFNRRKAAVEALQSQALHATSQQPLRKDKDKKNRSDIGAHQPGMSLSSSKVMMTKASVEPLNCSSWWPAIQCCSCLVRDATWREGFL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92599 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| R17 | Methylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Q8IW41 (MAPKAPK5) | Uniprot |
| K173 | Ubiquitination | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| S192 | Phosphorylation | Q8IW41 (MAPKAPK5) | Uniprot |
| K193 | Acetylation | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| K198 | Acetylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K200 | Acetylation | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| Y300 | Phosphorylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| Y326 | Phosphorylation | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K351 | Ubiquitination | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| K381 | Acetylation | Uniprot | |
| K387 | Acetylation | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| T416 | Phosphorylation | Uniprot |
研究背景
Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).
Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.
Cytoplasm. Cytoplasm>Cytoskeleton. Cell junction>Synapse. Cell projection>Axon. Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle membrane. Cell junction>Synapse>Presynapse.
Note: Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules (PubMed:15116257).
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with CDK14. Interacts with SEPTIN5. Interacts with SEPTIN7 (By similarity). Interacts with SEPTIN4. Interacts with VAMP2; the interaction inhibits interaction of VAMP2 with SYP (By similarity). Interacts with STX1A (By similarity).
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
研究領域
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
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