CSGALNACT1 Antibody - #AF9238

(1)  
製品: CSGALNACT1 Antibody
カタログ: AF9238
タンパク質の説明: Rabbit polyclonal antibody to CSGALNACT1
アプリケーション: WB
反応性: Human
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 61kDa; 61kD(Calculated).
ユニプロット: Q8TDX6
RRID: AB_2843428

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Pig(92%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(91%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
CSGALNACT1 Antibody detects endogenous levels of total CSGALNACT1.
RRID:
AB_2843428
引用形式: Affinity Biosciences Cat# AF9238, RRID:AB_2843428.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

4-N-acetylgalactosaminyltransferase 1; Beta4GalNAcT 1; beta4GalNAcT; Beta4GalNAcT-1; Beta4GalNAcT1; CGAT1_HUMAN; ChGn; Chondroitin beta-1; Chondroitin beta1 4 N acetylgalactosaminyltransferase; Chondroitin beta1 4 N acetylgalactosaminyltransferase 1; Chondroitin sulfate N acetylgalactosaminyltransferase 1; Chondroitin sulfate N-acetylgalactosaminyltransferase 1; CSGalNAcT 1; CsGalNAcT-1; Csgalnact1; FLJ11264; FLJ13760;

免疫原

免疫原:
Uniprot:

Q8TDX6(CGAT1_HUMAN) >>Visit HPA database.

遺伝子(ID):
CSGALNACT1(55790)
発現特異性:
Q8TDX6 CGAT1_HUMAN:

Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

タンパク質配列:
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAVLQEWEEQHRNYVSSLKRQIAQLKEELQERSEQLRNGQYQASDAAGLGLDRSPPEKTQADLLAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDELVEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLILFRPFGPIMKVKNEKLNMANTLINVIVPLAKRVDKFRQFMQNFREMCIEQDGRVHLTVVYFGKEEINEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKTSSKKT

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Pig
92
Chicken
91
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8TDX6 基板として

Site PTM Type Enzyme
T364 Phosphorylation
T370 Phosphorylation
T375 Phosphorylation
T486 Phosphorylation
Y490 Phosphorylation
S503 Phosphorylation
T527 Phosphorylation
S528 Phosphorylation

研究背景

機能:

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification. Moreover, is involved in the metabolism of aggrecan (By similarity).

PTMs:

N-glycosylated.

細胞の位置付け:

Golgi apparatus>Golgi stack membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

タンパク質ファミリー:

Belongs to the chondroitin N-acetylgalactosaminyltransferase family.

研究領域

· Metabolism > Glycan biosynthesis and metabolism > Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate.

· Metabolism > Global and overview maps > Metabolic pathways.

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