Phospho-TYK2 (Tyr1054) Antibody - #AF8002
| 製品: | Phospho-TYK2 (Tyr1054) Antibody |
| カタログ: | AF8002 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-TYK2 (Tyr1054) |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 134 kDa.; 134kD(Calculated). |
| ユニプロット: | P29597 |
| RRID: | AB_2843429 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8002, RRID:AB_2843429.
折りたたみ／展開
JTK 1; JTK1; Non receptor tyrosine protein kinase 2; Non receptor tyrosine protein kinase TYK2; Non-receptor tyrosine-protein kinase TYK2; OTTHUMP00000232745; OTTHUMP00000232746; OTTHUMP00000232748; Protein Tyrosine Kinase 2; TYK 2; Tyk2; TYK2_HUMAN; Tyrosine kinase 2;
免疫原
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
- P29597 TYK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P29597 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T67 | Phosphorylation | Uniprot | |
| Y292 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| Y423 | Phosphorylation | Uniprot | |
| Y433 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S723 | Phosphorylation | Uniprot | |
| K728 | Ubiquitination | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| K823 | Ubiquitination | Uniprot | |
| Y827 | Phosphorylation | Uniprot | |
| Y851 | Phosphorylation | Uniprot | |
| S884 | Phosphorylation | Uniprot | |
| K899 | Ubiquitination | Uniprot | |
| K930 | Ubiquitination | Uniprot | |
| K933 | Ubiquitination | Uniprot | |
| K945 | Ubiquitination | Uniprot | |
| K963 | Ubiquitination | Uniprot | |
| K1046 | Ubiquitination | Uniprot | |
| Y1054 | Phosphorylation | P29597 (TYK2) , P23458 (JAK1) | Uniprot |
| Y1055 | Phosphorylation | P29597 (TYK2) , P23458 (JAK1) | Uniprot |
| K1074 | Ubiquitination | Uniprot | |
| K1175 | Ubiquitination | Uniprot |
PTMs - P29597 酵素として
| Substrate | Site | Source |
|---|---|---|
| O15304 (SIVA1) | Y53 | Uniprot |
| O15304 (SIVA1) | Y162 | Uniprot |
| P17181 (IFNAR1) | Y466 | Uniprot |
| P17181 (IFNAR1) | Y481 | Uniprot |
| P29597 (TYK2) | Y1054 | Uniprot |
| P29597 (TYK2) | Y1055 | Uniprot |
| P42224-2 (STAT1) | Y701 | Uniprot |
| P51452 (DUSP3) | Y138 | Uniprot |
| P63244 (RACK1) | Y194 | Uniprot |
| Q13651 (IL10RA) | Y446 | Uniprot |
| Q13651 (IL10RA) | Y496 | Uniprot |
| Q9BZL6 (PRKD2) | Y438 | Uniprot |
研究背景
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Interacts with JAKMIP1.
The FERM domain mediates interaction with JAKMIP1.
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
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