PRPS1 Antibody - #AF7030

(2)  
製品: PRPS1 Antibody
カタログ: AF7030
タンパク質の説明: Rabbit polyclonal antibody to PRPS1
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 34 KD; 35kD(Calculated).
ユニプロット: P60891
RRID: AB_2843470

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(78%), Bovine(78%), Horse(78%), Sheep(78%), Rabbit(63%), Dog(0%), Chicken(67%), Xenopus(57%)
クローナリティ:
Polyclonal
特異性:
PRPS1 Antibody detects endogenous levels of total PRPS1.
RRID:
AB_2843470
引用形式: Affinity Biosciences Cat# AF7030, RRID:AB_2843470.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

ARTS; CMTX5; Deafness 2 perceptive congenital; Deafness X linked 2 perceptive congenital; DFN2; DFNX1; EC 2.7.6.1; KIAA0967; Phosphoribosyl pyrophosphate synthase I; Phosphoribosyl pyrophosphate synthetase I; PPRibP; Prps1; PRPS1_HUMAN; PRS I; PRS-I; PRSI; Ribose phosphate pyrophosphokinase I; Ribose-phosphate pyrophosphokinase 1;

免疫原

免疫原:
Uniprot:

P60891(PRPS1_HUMAN) >>Visit HPA database.

遺伝子(ID):
PRPS1(5631)
タンパク質の説明:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
タンパク質配列:
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
78
Horse
78
Bovine
78
Sheep
78
Chicken
67
Rabbit
63
Xenopus
57
Dog
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P60891 基板として

Site PTM Type Enzyme
K5 Ubiquitination
K18 Ubiquitination
R22 Methylation
K29 Ubiquitination
S36 Phosphorylation
S103 Phosphorylation
Y146 Phosphorylation
R156 Methylation
K176 Acetylation
K176 Ubiquitination
S180 Phosphorylation
R184 Methylation
K194 Acetylation
K194 Ubiquitination
R204 Methylation
K212 Acetylation
K212 Ubiquitination
T225 Phosphorylation
T228 Phosphorylation
K235 Ubiquitination
S238 Phosphorylation
T242 Phosphorylation
Y245 Phosphorylation
K280 Ubiquitination
S308 Phosphorylation
S310 Phosphorylation
Y311 Phosphorylation

研究背景

機能:

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

サブユニット構造:

Homodimer. The active form is probably a hexamer composed of 3 homodimers.

タンパク質ファミリー:

Belongs to the ribose-phosphate pyrophosphokinase family.

研究領域

· Metabolism > Carbohydrate metabolism > Pentose phosphate pathway.

· Metabolism > Nucleotide metabolism > Purine metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Metabolism > Global and overview maps > Carbon metabolism.

· Metabolism > Global and overview maps > Biosynthesis of amino acids.

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