Phospho-SLC16A1 (Ser213) Antibody - #AF7044
(2)
(5)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7044, RRID:AB_2843484.
折りたたみ／展開
FLJ36745; HHF7; MCT 1; MCT; MGC44475; Monocarboxylate transporter 1; Monocarboxylate transporter; Monocarboxylate transporter isoform 1; Monocarboxylic acid transporter 1; MOT1_HUMAN; Slc16a1; SLC16A1 protein; Solute carrier family 16 (monocarboxylic acid transporters) member 1; Solute carrier family 16 member 1 (monocarboxylic acid transporter 1); Solute carrier family 16 member 1;
免疫原
Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.
- P53985 MOT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
PTMs - P53985 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S33 | Phosphorylation | Uniprot | |
| Y34 | Phosphorylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| T466 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| T489 | Phosphorylation | Uniprot | |
| K494 | Methylation | Uniprot | |
| K494 | Ubiquitination | Uniprot | |
| S498 | Phosphorylation | Uniprot |
研究背景
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.
Cell membrane>Multi-pass membrane protein.
Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.
Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
参考文献
Application: WB Species: Rabbit Sample:
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