Phospho-TRAF7 (Ser61) Antibody - #AF7046
| 製品: | Phospho-TRAF7 (Ser61) Antibody |
| カタログ: | AF7046 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-TRAF7 (Ser61) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 67kD; 75kD(Calculated). |
| ユニプロット: | Q6Q0C0 |
| RRID: | AB_2843486 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7046, RRID:AB_2843486.
折りたたみ／展開
E3 ubiquitin protein ligase TRAF7; E3 ubiquitin-protein ligase TRAF7; RFWD1; Ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TRAF7; TRAF7_HUMAN;
免疫原
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
- Q6Q0C0 TRAF7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTPSSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6Q0C0 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y9 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| T21 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| T65 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| T149 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K387 | Methylation | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| S658 | Phosphorylation | Uniprot |
研究背景
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
Phosphorylated by MAP3K3.
Ubiquitinates itself upon phosphorylation.
Cytoplasmic vesicle.
Note: Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.
Belongs to the WD repeat TRAF7 family.
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