製品: Phospho-ADAM9 (Thr761) Antibody
カタログ: AF7059
タンパク質の説明: Rabbit polyclonal antibody to Phospho-ADAM9 (Thr761)
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Horse, Rabbit
分子量: 91kDa,105kDa; 91kD(Calculated).
ユニプロット: Q13443
RRID: AB_2843499

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(89%), Horse(100%), Rabbit(90%)
クローナリティ:
Polyclonal
特異性:
Phospho-ADAM9 (Thr761) Antibody detects endogenous levels of ADAM9 only when phosphorylated at Thr761.
RRID:
AB_2843499
引用形式: Affinity Biosciences Cat# AF7059, RRID:AB_2843499.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

A disintegrin and metalloproteinase domain 9; ADAM 9; ADAM metallopeptidase domain 9; Cellular disintegrin related protein; Cone rod dystrophy 9; CORD9; Disintegrin and metalloproteinase domain 9; Disintegrin and metalloproteinase domain containing protein 9; KIAA0021; MCMP; MDC 9; MDC9; Meltrin gamma; Metalloprotease disintegrin cysteine rich protein 9; Mltng; Myeloma cell metalloproteinase;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q13443 ADAM9_HUMAN:

Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.

タンパク質配列:
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Rabbit
90
Pig
89
Sheep
78
Bovine
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q13443 基板として

Site PTM Type Enzyme
K85 Ubiquitination
K184 Acetylation
K188 Acetylation
Y213 Phosphorylation
Y250 Phosphorylation
S364 Phosphorylation
S377 Phosphorylation
S379 Phosphorylation
K392 Ubiquitination
K397 Ubiquitination
K450 Ubiquitination
S451 Phosphorylation
Y457 Phosphorylation
K533 Acetylation
K546 Ubiquitination
K561 Ubiquitination
T735 Phosphorylation
Y736 Phosphorylation
S738 Phosphorylation
K741 Ubiquitination
S747 Phosphorylation
S752 Phosphorylation
S758 O-Glycosylation
S758 Phosphorylation
T761 O-Glycosylation
T761 Phosphorylation
Y769 Phosphorylation
R772 Methylation
T777 O-Glycosylation
T777 Phosphorylation
Y778 Phosphorylation
K781 Ubiquitination
K796 Ubiquitination
S798 Phosphorylation
S799 Phosphorylation
Y815 Phosphorylation
S816 Phosphorylation
S817 Phosphorylation
T819 Phosphorylation

研究背景

機能:

Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.

May act as alpha-secretase for amyloid precursor protein (APP).

PTMs:

Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.

Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.

サブユニット構造:

Interacts with SH3GL2 and SNX9 through its cytoplasmic tail. Interacts with ITGA6.

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