Phospho-osterix (Thr319) Antibody - #AF7080
| 製品: | Phospho-osterix (Thr319) Antibody |
| カタログ: | AF7080 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-osterix (Thr319) |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Rabbit, Dog, Xenopus |
| 分子量: | 46kDa; 45kD(Calculated). |
| ユニプロット: | Q8TDD2 |
| RRID: | AB_2843520 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7080, RRID:AB_2843520.
折りたたみ／展開
MGC126598; Osterix; Osx; Sp 7; SP7; Sp7 transcription factor; SP7_HUMAN; Transcription factor Sp7; Zinc finger protein osterix;
免疫原
- Q8TDD2 SP7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPGGSPEQSNLLEI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8TDD2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S30 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| S76 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| S80 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| K230 | Ubiquitination | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| K307 | Acetylation | Uniprot | |
| K312 | Acetylation | Uniprot | |
| T319 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| T364 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| S370 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| T397 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot |
研究背景
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences.
Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours.
Propionylated. Depropionylation at Lys-371 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts.
Nucleus.
Restricted to bone-derived cell.
Interacts with RIOX1; the interaction is direct and inhibits transcription activator activity.
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Belongs to the Sp1 C2H2-type zinc-finger protein family.
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