Phospho-TFAP2C (Ser434) Antibody - #AF7082
| 製品: | Phospho-TFAP2C (Ser434) Antibody |
| カタログ: | AF7082 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-TFAP2C (Ser434) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 49kDa; 49kD(Calculated). |
| ユニプロット: | Q92754 |
| RRID: | AB_2843522 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7082, RRID:AB_2843522.
折りたたみ／展開
Activating enhancer binding protein 2 gamma; Activating enhancer-binding protein 2 gamma; AP2-gamma; AP2C_HUMAN; AP2g; AP2gamma; ERF 1; ERF1; Estrogen receptor factor 1; hAP 2g; hAP2g; TFAP 2C; TFAP 2G; Tfap2c; TFAP2G; Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma); Transcription factor AP 2 gamma; Transcription factor AP-2 gamma; Transcription factor ERF 1; Transcription factor ERF-1; Transcription factor ERF1;
免疫原
- Q92754 AP2C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYFPPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGRPAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNVDDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPGDQSPADSNKTLEKMEKHRK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92754 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K10 | Sumoylation | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| K444 | Ubiquitination | Uniprot | |
| K447 | Ubiquitination | Uniprot |
研究背景
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Sumoylated on Lys-10; which inhibits transcriptional activity.
Nucleus.
Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1.
The PPxY motif mediates interaction with WWOX.
Belongs to the AP-2 family.
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