Phospho-IGFBP3 (Ser183) Antibody - #AF3203
| 製品: | Phospho-IGFBP3 (Ser183) Antibody |
| カタログ: | AF3203 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-IGFBP3 (Ser183) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Dog |
| 分子量: | 30 kDa; 32kD(Calculated). |
| ユニプロット: | P17936 |
| RRID: | AB_2834635 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3203, RRID:AB_2834635.
折りたたみ／展開
Acid stable subunit of the 140 K IGF complex; Binding protein 29; Binding protein 53; BP 53; BP53; Growth hormone dependent binding protein; IBP 3; IBP-3; IBP3; IBP3_HUMAN; IGF binding protein 3; IGF-binding protein 3; IGFBP 3; IGFBP-3; IGFBP3; Insulin Like Growth Factor Binding Protein 3; Insulin-like growth factor binding protein 3 precursor; Insulin-like growth factor-binding protein 3;
免疫原
- P17936 IBP3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P17936 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T7 | Phosphorylation | Uniprot | |
| N116 | N-Glycosylation | Uniprot | |
| N136 | N-Glycosylation | Uniprot | |
| S138 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S140 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S145 | Phosphorylation | Uniprot | |
| S148 | O-Glycosylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| S151 | O-Glycosylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| S153 | O-Glycosylation | Uniprot | |
| S155 | O-Glycosylation | Uniprot | |
| S156 | O-Glycosylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| T157 | O-Glycosylation | Uniprot | |
| S161 | O-Glycosylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | P78527 (PRKDC) | Uniprot |
| Y190 | Phosphorylation | Uniprot | |
| S192 | O-Glycosylation | Uniprot | |
| S194 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| T195 | O-Glycosylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| N199 | N-Glycosylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| Y210 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| Y246 | Phosphorylation | Uniprot | |
| T277 | O-Glycosylation | Uniprot |
研究背景
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Phosphorylated by FAM20C in the extracellular medium.
Secreted.
Expressed by most tissues. Present in plasma.
Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219.
The thyroglobulin type-1 domain mediates interaction with HN.
研究領域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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