Phospho-IFNGR1 (Tyr457) Antibody - #AF7234
| 製品: | Phospho-IFNGR1 (Tyr457) Antibody |
| カタログ: | AF7234 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-IFNGR1 (Tyr457) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 50~100kD; 54kD(Calculated). |
| ユニプロット: | P15260 |
| RRID: | AB_2843674 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7234, RRID:AB_2843674.
折りたたみ／展開
Antiviral Protein Type II; Antiviral protein, type 2; AVP type II; AVP, type 2; CD 119; CD119; CD119 antigen; CDw119; FLJ45734; IFN gamma R alpha; IFN gamma R; IFN gamma R1; IFN-gamma receptor 1; IFN-gamma-R1; IFNG R1; IFNGR 1; IFNGR; IFNGR1; Immune interferon receptor 1; Immune interferon receptor for; INGR1_HUMAN; Interferon gamma receptor 1; Interferon gamma receptor alpha chain; Interferon gamma receptor alpha chain precursor;
免疫原
- P15260 INGR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P15260 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K115 | Ubiquitination | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| T295 | Phosphorylation | Uniprot | |
| T298 | Phosphorylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| Y304 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| T309 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| S391 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| Y397 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| Y440 | Phosphorylation | Uniprot | |
| K450 | Ubiquitination | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| Y457 | Phosphorylation | P23458 (JAK1) | Uniprot |
| K459 | Ubiquitination | Uniprot | |
| Y479 | Phosphorylation | Uniprot |
研究背景
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents.
Phosphorylated at Ser/Thr residues.
Cell membrane>Single-pass type I membrane protein.
Monomer. Heterodimer with IFNGR2, to form the IFNG receptor complex. Interacts with JAK1.
Belongs to the type II cytokine receptor family.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
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